Hemoglobin electrophoresis and high-performance liquid chromatography (HPLC) confirmed a heterozygous hemoglobin C (HbC), previously unrecognized in the patient and his family. This case highlights the importance of considering hemoglobinopathies in the differential diagnosis of microcytic hypochromic anemia, even when iron deficiency appears to be the most likely cause. This evidence concerns the gene KRT88P and hypochromic anemia.