Multivariate analysis identified severe GERD (β = 0.31, p < 0.001), elevated CRP (β = 0.27, p = 0.002), and higher BMI (β = 0.22, p = 0.008) as independent predictors of hypertension.<h4>Conclusion</h4>GERD in pediatric populations is associated with progressive cardiovascular alterations, including rising blood pressure, autonomic dysregulation, systemic inflammation, and early cardiac remodeling. The gene discussed is CRP; the disease is hypertensive disorder.