PROMIS-Sleep was moderately associated with IL-8 (<i>r<sub>s</sub></i> = 0.39; 95% CI 0.06, 0.64; <i>p</i> = 0.021).<h4>Conclusions</h4>While preliminary, our findings suggest that associations between inflammatory biomarkers and depression may not be consistent across all depressive measures or symptom dimensions. This evidence concerns the gene CXCL8 and depressive symptom measurement.