IL-4 demonstrated significant negative associations with PROMIS-Depression (<i>r<sub>s=</sub></i> 0.35; 95% CI -0.61, -0.03; <i>p</i> = 0.034) and PROMIS-Anxiety scores (<i>r<sub>s</sub></i> = -0.37; 95% CI -0.62, -0.05; <i>p</i> = 0.025), but associations with CES-D were not significant. This evidence concerns the gene IL4 and major depressive disorder.