Within the SRPE group, prolactin levels were negatively correlated with erectile function and positively correlated with psychological distress (nominal p < 0.05), whereas no such associations were observed in the control group.<h4>Conclusion</h4>SRPE may be associated with a specific psychoneuroendocrine profile in which psychological distress and prolactin dynamics are linked to secondary erectile dysfunction. The gene discussed is PRL; the disease is erectile dysfunction.