The M39<sup>1.34</sup>R variant, located in transmembrane helix 1, is associated with sector retinitis pigmentosa and exhibits pronounced thermal and chemical destabilization.<h4>Methods</h4>We investigated whether geraniol, a natural monoterpenoid alcohol with reported cytoprotective properties, can act as a pharmacological stabilizer of rhodopsin. Here, RHO is linked to retinitis pigmentosa.