SPRY1 and asthma: Knockdown of SPRY1 reversed the effects of miR-18a-5p inhibition, confirming its role in mediating ASMC phenotypic changes.<h4>Conclusion</h4>miR-18a-5p promotes ASMC phenotypic switching and airway remodeling in asthma by targeting SPRY1 and activating the RAS-MAPK signaling pathway.