The model, combined with pathologic T stage in a nomogram, showed high predictive accuracy for patient survival.<h4>Results</h4>Totally 13 DE-ERGs were gained by overlapping 3,866 DEGs and 74 ERGs, and SLC26A6, TYRO3, and PDK4 were identified as prognosis genes for constructing a risk model with highly proficient in assessing the risk of HCC patients. The gene discussed is SLC26A6; the disease is hepatocellular carcinoma.