This study aimed to analyze the relationship of CHGA and UCHL1 with the epithelial-mesenchymal transition (EMT) and the Rho/ERK/NFκB signaling pathway in OXA-resistant CRC cells.<h4>Methods</h4>Resistant colorectal cancer cells (HCT-116/OxR) were established using progressive exposure to oxaliplatin (OXA). The gene discussed is NFKB1; the disease is colorectal cancer.