On the based that secreted frizzled-related protein 1 (SFRP1) was demonstrated to be a regulator on B-ALL BMSC osteogenesis, BMSC-targeted liposomal nanocarriers were engineered to encapsulate lentiviral particles carrying therapeutic shSFRP1 RNA and grafted with E7 peptide (shSFRP1@Lipo-E7), enabling cell-specific gene silencing in BMSCs. This evidence concerns the gene FRZB and acute lymphoblastic leukemia.