Among these, HPS6, CTBP2,RABGGTA, SORT1,ALKBH2,BCL2L10, AOC2,and PON2 were significantly downregulated, whereas SLC4A7,PDE4D, ERLIN2,and DNM2 were markedly upregulated (P < 0.05).<h4>Conclusion</h4>These findings demonstrate that DEHP promotes PAH pathogenesis by modulating specific genes and associated pathways. Here, PON2 is linked to pulmonary arterial hypertension.