Tissue-specific insulin-mediated glucose uptake was derived from PET imaging, while CT provided data on radiodensity, volume, fat, and calcifications.<h4>Results</h4>A strong inverse correlation was observed between myocardial and liver ΔSUV (r=-0.74, p=2×10<sup>-7</sup>), thus suggesting the liver-heart metabolic axis in T2D. The gene discussed is INS; the disease is type 2 diabetes mellitus.