This study is aimed at identifying disease-associated CD8<sup>+</sup> T cell subpopulations and potential therapeutic targets through integrative multiomics analysis.<h4>Methods</h4>We performed bulk RNA sequencing on peripheral blood from 130 patients (66 ICH and 64 hypertension controls) across two independent cohorts, combined with single-cell RNA sequencing of 13 patients. Here, CD8A is linked to Hypertension.