However, studies examining these biomarkers as predictors of MetS, particularly in the context of age and body mass index (BMI), remain limited and inconsistent.<h4>Objective</h4>The objective of this study is to evaluate the association of serum galectin-1, leptin, adiponectin, and the adiponectin/leptin ratio (A/L) with MetS, and to identify their predictive value across different age and BMI groups.<h4>Methods</h4>In this prospective cross-sectional study, 122 participants were enrolled and categorized into MetS (n = 48) and healthy control (n = 74) groups based on NHLBI/AHA criteria. This evidence concerns the gene LEP and metabolic syndrome.