Polydatin (PD), a natural compound, has shown anti-inflammatory potential, but its role in asthma-related airway remodeling and the underlying mechanisms involving the P2X7R-NLRP3 inflammasome axis and autophagy remain unclear.<h4>Methods</h4>An ovalbumin-induced asthmatic mouse model and primary airway smooth muscle cells (ASMCs) were used. Here, NLRP3 is linked to asthma.