Silencing P2X7R enhanced AMPK phosphorylation, underscoring its role in the pathway.<h4>Conclusion</h4>PD attenuates airway remodeling in asthma by inhibiting the ATP/P2X7R-NLRP3 inflammasome axis and subsequent excessive autophagy, partly through modulation of the LKB1/AMPK/mTOR signaling pathway. The gene discussed is STK11; the disease is asthma.