ING5 and giant cell reparative granuloma: H3K9ac and ING5 were associated with aggressive characteristics in the CGCG (p < 0.05).<h4>Conclusion</h4>H3K9 hyperacetylation highlights the significance of this epigenetic event in the aggressiveness of Giant Cell Lesions and may indicate their potential for aggressive behavior, thereby providing information to improve treatment strategies, particularly for Central Giant Cell Granuloma.