WDFY3 and Parkinson disease: As impaired autophagy is increasingly implicated in Parkinson's disease (PD) and other neurodegenerative disorders, we investigated whether Wdfy3 haploinsufficiency produces early molecular and cellular signatures of neurodegeneration in Wdfy3<sup>+/lacZ</sup> mice, given that these diseases often exhibit presymptomatic alterations preceding overt clinical manifestations.