The ER‐localized isomerase FK506‐binding protein 10 (FKBP10) is essential for extracellular matrix homeostasis, but its systemic role in cancer immune regulation and therapeutic response remains unclear.<h4>Methods</h4>A pan‐cancer analysis of 33 TCGA tumor types integrated copy number variation, DNA methylation, and mutation data to elucidate FKBP10 regulation. Here, FKBP10 is linked to neoplasm.