<h4>Objective</h4>We are aimed at analyzing the correlation between contrast-enhanced ultrasound (CEUS) quantitative perfusion parameters and serum levels of vascular endothelial growth factor (VEGF) and C-X-C motif chemokine ligand 12 (CXCL-12) in a rabbit model of diabetic foot, and exploring the value of CEUS in evaluating microcirculatory lesions of diabetic foot.<h4>Methods</h4>Ten New Zealand white rabbits were intravenously injected with alloxan to induce diabetes (fasting blood glucose > 16 mmol/L, accompanied by symptoms of polydipsia, polyphagia, and polyuria). Here, CXCL12 is linked to Polyphagia.