LMNA and Hutchinson-Gilford progeria syndrome: The primary objective of this report is to present a comprehensive multidisciplinary management strategy for traumatic EDH in a 15-year-old HGPS patient, highlighting the critical interplay between progerin-induced vascular stiffening, reduced intracranial compliance, and the formidable anesthetic challenges encountered in the oldest reported survivor of this pathology.<h4>Case presentation</h4>A 15-year-old female with HGPS presented with a right frontoparietal EDH following a ground-level fall.