To identify potential therapeutics, we performed drug-signature matching using a public single-cell perturbation dataset to identify compounds capable of reversing LAR-associated, cell-specific transcriptional changes.<h4>Results</h4>A combined set of 109 LAR-mRNA biomarkers was identified and shown to predict asthma exacerbations, with stronger performance in males than females. The gene discussed is PTPRF; the disease is asthma.