Experimental validation confirmed that PPARG modulation significantly influenced ferroptosis-associated neuronal injury both <i>in vitro</i> and <i>in vivo</i>.<h4>Conclusion</h4>These findings identify PPARG as a key regulator linking ferroptosis and neuroinflammation in Alzheimer's disease. The gene discussed is PPARG; the disease is early-onset autosomal dominant Alzheimer disease.