LGALS3 and Sepsis: We conducted an integrated translational investigation combining clinical observation (87 septic patients, 27 healthy volunteers) with preclinical Gal-3 removal using an anti-Gal-3 apheresis column in two sepsis models: a rat cecal ligation and puncture (CLP) model (<i>n </i>= 48) and a porcine lipopolysaccharide (LPS)-induced model (<i>n</i> = 31).