MTOR and lung adenocarcinoma: KNL1 overexpression significantly increased phosphorylated AMPK (p-AMPK) expression but decreased phosphorylated mTOR (p-mTOR) expression in RSL3-treated LUAD cells; conversely, it inhibited p-AMPK expression and activated p-mTOR.<h4>Conclusion</h4>KNL1 promotes lung adenocarcinoma progression by suppressing ferroptosis through regulation of the AMPK-mTOR signaling pathway.