ALB and Hypoalbuminemia: This study evaluates the effect of TGs on serum albumin levels in RA patients compared to methotrexate (MTX) or combination therapy (TGs + MTX) and identifies associated risk factors for hypoalbuminemia.<h4>Materials and methods</h4>We conducted a retrospective study of 146 RA patients on TGs, 62 on MTX, and 54 on TGs + MTX.