Frequent thrombophilia-related variants occurred in <i>F5</i>, <i>SERPINC1</i>, <i>MTHFR</i>, and <i>FII</i>, and inherited thrombocytopenias were linked to <i>MPL</i>, <i>ANKRD26</i>, <i>THPO</i>, <i>DIAPH1</i>, and <i>ADAMTS13</i>. This evidence concerns the gene SERPINC1 and Rare hereditary thrombophilia.