We aimed to evaluate the expression of the IR, IGF-1 receptor (IGF-1R), and associated signaling protein expression in TNBC and their correlations with demographic and metabolic parameters in a population of women with TNBC.<h4>Methods</h4>We identified cases of TNBC from our multi-institutional, cross-sectional study of self-identified Black and White women with newly diagnosed breast cancer. Here, INSR is linked to breast carcinoma.