Through targeted whole-genome sequencing and replications in sex-specific cohorts with ST-elevation myocardial infarction (STEMI) or non-ST-elevation myocardial infarction (NSTEMI) we discovered a novel haplotype in the butyrophilin-like 2 (BTNL2) gene that predisposes men to NSTEMI. Here, BTNL2 is linked to ST Elevation Myocardial Infarction.