A moderate significant positive correlation was observed between the duration of status epilepticus and serum Nf-L concentrations (Pearson r = 0.48, p  = 0.02).<h4>Conclusion</h4>Our data indicate that single and acute repetitive seizures likely do not cause significant neuronal injury as assessed by Nf-L concentrations in serum and CSF. The gene discussed is NEFL; the disease is status epilepticus.