After confounder adjustment, cord blood interleukin-4 (odds ratio = 2.38) and interleukin-10 (odds ratio = 0.78) emerged as independent risk and protective factors for childhood allergic diseases, respectively.<h4>Conclusions</h4>Normal maternal prenatal vitamin D status is tied to lower allergic disease risk in offspring, with umbilical cord blood cytokines (especially interleukin-4 and interleukin-10) potentially mediating this relationship in early childhood. This evidence concerns the gene IL4 and allergic disease.