Path analysis indicated direct effects of Ki-67 LI and TERT mutation on ITSS grade, and an indirect effect of IDH1 mutation on ITSS grade mediated through Ki-67 LI.<h4>Conclusion</h4>7-T SWI-derived ITSS grade predicts histologic grade, Ki-67 LI, and TERT promoter mutation status in gliomas. The gene discussed is IDH1; the disease is glioma.