Proteomic analysis of plasma inflammatory mediators showed a significant increase in the pro-inflammatory cytokine TNFa (<i>P</i> < 0.05) and the chemokines CXCL10, CCL3, CCL19, CSF1 (<i>P</i> < 0.05) and CXCL12 (<i>P</i> < 0.01) in FTD individuals compared to healthy controls. Here, TNF is linked to frontotemporal dementia.