SLCO1C1 and Anxiety: Finally, evaluation of hippocampus-dependent behaviors did not reveal alterations upon neuronal Mct8/Oatp1c1 deficiency, whereas M/O dKO mice exhibit abnormal anxiety-related behavior.<h4>Conclusions</h4>Together, these data point to the central hypothyroid state of M/O dKO mice as the main cause of the neuronal alterations present in these animals and rule out a major cell-autonomous function of Mct8/Oatp1c1 in GABAergic or glutamatergic neurons.