In the non-AD tauopathy group, strong correlations were observed with MMSE and TMT Part B performance.<h4>Discussion</h4>Neuropsychological performance and regional tau pathology distribution are correlated in patients with tauopathy, with differences between AD continuum and non-AD tauopathy.<h4>Clinical trial registration</h4>This trial is registered with UMIN Clinical Trials (UMIN-CTR number: 000032027); submitted for registration on March 30, 2018; first patient enrolment was on July 3, 2018. The gene discussed is MAPT; the disease is Alzheimer disease.