However, their association with childhood-onset cancers, such as B-cell precursor acute lymphoblastic leukemia (pre-B ALL), remains unexplored.<h4>Aim</h4>To describe the mutational profile of <i>CHEK2</i> GVs in a cohort of Mexican children diagnosed with pre-B ALL and review the mutational landscape of <i>CHEK2</i> GVs in children with pre-B ALL.<h4>Methods</h4>Next-generation exome sequencing was performed on 73 Mexican children with pre-B ALL. Here, CHEK2 is linked to acute lymphoblastic leukemia.