The abnormal expression of calcium/calmodulin-dependent serine protein kinase (CASK) plays an important role in the tumorigenesis of many cancers; however, the role of CASK in the potential therapeutic value of osteosarcoma has not been reported.<h4>Methods</h4>The Gene Expression Omnibus (GEO) database was used to analyze the expression levels of CASK in osteosarcoma patients. This evidence concerns the gene CASK and osteosarcoma.