Finally, BRG1 knockdown similarly suppressed fibrotic activation in human CFs.<h4>Conclusion</h4>Our study defines a novel BRG1/ZEB1/PP2A transcriptional axis as a key driver of myocardial fibrosis and suggests BRG1 as a potential therapeutic target for mitigating fibrotic remodeling after MI. This evidence concerns the gene SMARCA4 and myocardial infarction.