Secondary outcomes included delirium days, intraoperative temperature, pain scores (days 1-3), MoCA (days 1 and 3), serum S100β, IL-6, TNF- α, cortisol, and perioperative adverse events.<h4>Results</h4>Of the 174 randomized patients, 153 completed the study and were included in the final analysis. Here, S100B is linked to delirium.