In joint exposure analyses, participants with both high CRP and high TyG had the greatest risks across outcomes, including CAD (HR 1.48, 95% CI: 1.40-1.56), CKD (HR 1.52, 95% CI: 1.40-1.64), T2DM (HR 3.63, 95% CI: 3.35-3.93), and multimorbidity (HR 2.64, 95% CI: 2.47-2.82).<h4>Conclusions</h4>CRP, TyG, and CTI were strongly associated with both the onset and progression of the cardiovascular-renal-diabetes cluster. This evidence concerns the gene CRP and chronic kidney disease.