Furthermore, TUBB2A was found to be associated with key regulators of cholesterol metabolism, including HMGCR, LDLR, SREBP2, and CYP7A1, suggesting its role in regulating cholesterol metabolic homeostasis.<h4>Discussion</h4>TUBB2A plays a key role in promoting HCC tumorigenesis and is associated with adverse clinical outcomes. Here, TUBB2A is linked to hepatocellular carcinoma.