This study aimed to evaluate USP21 protein expression in CRC tissues and develop a USP21-based nomogram for individualized prediction of postoperative overall survival (OS).<h4>Methods</h4>A total of 115 CRC patients who underwent radical resection at the Affiliated Kunshan Hospital of Jiangsu University between 2018 and 2019 were retrospectively included. This evidence concerns the gene USP21 and colorectal carcinoma.