In co-culture assays, Niclosamide enhanced T cell infiltration, reduced exhaustion under hypoxic conditions, and improved T cell-mediated tumor killing.<h4>Discussion</h4>These findings identify Niclosamide as a potent dual STAT1/STAT3 inhibitor capable of reversing IFN-γ- and hypoxia-driven immune evasion. The gene discussed is STAT3; the disease is neoplasm.