This study aimed to evaluate the therapeutic potential of mitochondrial transplantation in experimental autoimmune encephalomyelitis (EAE), a murine model of MS, by investigating its effects on immune modulation, mitochondrial function, and tissue integrity.<h4>Methods</h4>EAE was induced in mice using myelin oligodendrocyte glycoprotein. This evidence concerns the gene MOG and experimental autoimmune encephalomyelitis.