Here, we have addressed this issue in lung squamous cell carcinoma (LUSC) using the Rosa26<sup>LSL-Sox2-IRES-GFP</sup>; Nkx2-1<sup>fl/fl</sup>; Lkb1<sup>fl/fl</sup> mouse model, where we demonstrate increased TAN survival with a rise in Bcl-xL similarly to LUAD. The gene discussed is SOX2; the disease is squamous cell lung carcinoma.