Moreover, the expression and function of key members were verified by reverse transcription quantitative polymerase chain reaction (RT-qPCR), cell counting kit-8 (CCK-8) and cell proliferation experiments in clinical samples and cell lines.<h4>Results</h4>Multiple members of the SRSF family (e.g., SRSF1, SRSF2, SRSF3, SRSF6, SRSF7, SRSF9, SRSF10) were found to be significantly upregulated in NSCLC tissues and cell lines. This evidence concerns the gene SRSF3 and non-small cell lung carcinoma.