SRSF2 and non-small cell lung carcinoma: In vitro experiments confirmed that knockdown of SRSF1, SRSF2, SRSF6, SRSF9 and SRSF10 significantly inhibited the proliferation of NSCLC cells.<h4>Conclusions</h4>This study systematically delineates the expression and functional landscape of the SRSF family in NSCLC, confirming their potential as prognostic biomarkers and therapeutic targets.