MR and colocalization analyses were conducted to identify genetically supported candidates related to CTEPH.<h4>Results</h4>scRNA-seq analysis revealed altered immune composition, with a modest increase in NK cells and an angiogenesis-associated enrichment of monocytes and HSC-G-CSF cells in CTEPH patients, accompanied by activation of toll-like receptor and MAPK signaling pathways. The gene discussed is CSF3; the disease is chronic thromboembolic pulmonary hypertension.