ALB and brain neoplasm: MVMR analysis demonstrated direct effects of blood albumin, along with CSF metabolites such as alpha-hydroxyisocaproate, 1-ribosyl-imidazoleacetate, 5-methylthioadenosine, N1-methylinosine, and urate, independent of other factors.<h4>Conclusions</h4>This study reveals metabolite-brain tumor links, shows biomarker potential for screening and prevention, and offers new oncology insights for mechanisms and therapies.