<h4>Background</h4>This study is aimed at distinguishing the phenotypes of low-grade gliomas based on the P53 signaling pathway gene set, revealing the transcriptomic changes in different phenotypes, screening phenotype-related feature genes, constructing a TP53 score, quantitatively describing TP53-related phenotypes, and predicting the response of glioma patients to chemotherapy.<h4>Methods</h4>We obtained transcriptomic sequencing data of low-grade glioma samples from the Cancer Genome Atlas (TCGA) database. Here, TP53 is linked to glioma.