Furthermore, Rb1 administration evidently repressed the phosphorylation of NF-κB, IKKβ, and IκBα in the aging mice.<h4>Conclusion</h4>Rb1 may alleviate aging-related cognitive impairment by suppressing hippocampal inflammation, potentially through modulation of the NF-κB signaling pathway. Here, NFKBIA is linked to Cognitive impairment.