Ice cryotherapy significantly reduced arthritis severity and joint damage, decreased aortic COX-2 and p47phox expression, but increased VCAM-1 expression, and markedly reduced aortic infiltration by CD4<sup>+</sup>, CD8<sup>+</sup> T cells, and Tc17 cells, without affecting circulating leukocyte counts or plasma OPG and SOST. The gene discussed is CD4; the disease is arthritic joint disease.