After the 6-month treatment with HP-HD weekly, the anemia and nutritional status were improved significantly, indicating by increasing hemoglobin (<i>p</i> = 0.006) and albumin (<i>p</i> = 0.043), and decreasing erythropoiesis-stimulating agent (ESA) resistance index (ERI) <i>(p</i> = 0.032).<b>Conclusions:</b> Our findings suggested that the HP-HD might perform best in eliminating pCS, and HP-HD and HDF achieved equal clearances of middle-molecular toxins. The gene discussed is ALB; the disease is anemia (phenotype).